JK null alleles identified from Japanese individuals with Jk(a-b-) phenotype

摘要

The Kidd blood group system consists of three common phenotypes: Jk(a+b-), Jk(a-b+) and Jk(a+b+), and one rare phenotype, Jk(a-b-). Jka/Jkb polymorphism is associated with c.838GA (p.Asp280Asn) in exon 9 of the JK (SLC14A1) gene, and the corresponding alleles are named JK*01 and JK*02. The rare phenotype Jk(a-b-) was first found in a Filipina of Spanish and Chinese ancestry, and to date, several JK null alleles responsible for the Jk(a-b-) phenotype have been reported. We report seven novel JK null alleles, 4 with a JK*01 background and 3 with a JK*02 background, identified from Jk(a-b-) Japanese.