Acute graft-versus-host disease: More than just alloreactivity

摘要

a GVHD is induced by alloreactivity of donor T-cells against recipient (host) tissues. It requires genetic disparity between donor and recipient. Tissue injury occurs both from direct T-cell cytotoxicity and production of inflammatory cytokines.2 Risk factors for development of aGVHD include HLA disparity, use of unrelated donors, and donor alloimmunization. Viral infections such as cytomegalovirus may produce immune activation leading to development of GVHD.