Non-phthalate plasticizer DENT preserves adequate blood component quality during storage in PVC blood bags

摘要

Background and objectives Commercial blood bags are predominantly made of polyvinyl chloride (PVC) plasticized with di(2-ethylhexyl) phthalate (DEHP). DEHP is favourable for storage of red blood cells (RBC). Historically, removal of DEHP from blood bags has been linked to unacceptable haemolysis levels. Oncoming regulatory restrictions for DEHP due to toxicity concerns increase the urgency to replace DEHP without compromising RBC quality. Di(2-ethylhexyl) terephthalate (DEHT) is one suggested substitute. The aim of this study was to compare PVC-DEHT to PVC-DEHP blood bags using additive solutions saline- adenine-glucose-mannitol (SAGM) and phosphate-adenine-glucose-guanosine- saline-mannitol (PAGGSM), to determine whether DEHT can maintain acceptable component quality.