Systemic mastocytosis

摘要

Here, Ophir et al present a detailed analysis of an in vivo model, in which the phenotypic properties of expanded CD8+ veto cells (central memory phenotype) are studied. In addition, veto cell conjugates with anti-donor T cells are visualized by 2-photon microscopy and the modified cells now show efficacy both by confining anti-donor T cells to the lymph nodes and also inducing their deletion, whereas previous preparations that did not promote lymph node homing failed to do so. In aggregate, these studies elegantly demonstrate a substantial advance in cellular therapy engineering of veto cells in an in vivo preclini-cal model. Translation of this approach into the human setting has the potential to have a substantial impact on immunoregulation by veto cell-based cellular therapies in general and on BMT medicine in particular.