Synthesis and anti-mycobacterial activity of multicomponent Biginelli reaction catalysed by surfactant in aqueous media.

摘要

A method for the synthesis of 4-aryl-3,4-dihydropyrimidine-2(1H)-ones/thione (Biginelli reaction) from 1,3-dicarbonyl compound, substituted aldehydes and urea/thiourea in the presence of sodium dodecyl sulphate (SDS) novel catalyst under two experimental conditions is described. Using these methods title compounds were produced in high yield. Synthesized compounds were evaluated for their antibacterial, antifungal and anti-tubercular activity. 5-(ethoxycarbonyl)-4-(4-chlorophenyl)-6-methyl-3,4-dihydropyrimidine-2(1H)-thione and 5-(carboethoxy)-4-(4-chlorophenyl)-6-methyl-3,4-dihydropyrimidine-2(1H)-one showed excellent activity due to chlorine at C-4 of the phenyl ring.