Intravenous ketamine-dexmedetomidine induction-anaesthesia in dogs

摘要

Groups of 6 healthy male mix-breeddogs were given intravenous 2mg/kg Ketamine (KM) with 1ug/kg Dexmedetomidine (DX) (2/1),1mg/kg KM with 2μg/kg DX (1/2) or 1mg/kg KM with 1μg/kg DX (1/1). Anesthesia andcardiorespiratory function were evaluated before and for 60 minutes after induction. Sedation,analgesia, muscle relaxation and recovery were not different between treatments (p > 0.05).However intubation was faster in dogs given 2/1 dose; but head uprising and sternalrecumbency, slower (P < 0.05). Heart rates decreased significantly in dogs given 1/2 and 1/1dose at several time points (P < 0.05). Arterial blood pressure was beyond the reference range.Respiratory data did not show any significant differences. Co-administration of intravenous KMand DX at different doses could facilitate tracheal intubation and 2/1 doses may provideoptimal cardiovascular respiratory conditions. Subjective scores must be interpreted withcaution.