Response: Yes, cGMP plays a stimulatory role in platelet activation

摘要

We are grateful for the opportunity to reply to Gambaryan et al1 who dispute conclusions of our recent publication.2 In our study, we have shown that soluble guanylyl cyclase (sGC) plays biphasic roles in platelet activation, a stimulatory role during platelet activation induced by low-dose platelet agonists and an inhibitory role when stimulated with high or pharmacologic concentrations of NO donors.