Channeling the homocysteine chapel.

摘要

Hyperhomocysteinemia (HHcy), a potent risk factor for cardiovascular disease, is associated with impaired endothelium-dependent vasodilation. In this issue of Blood, Cheng et al report that severe HHcy causes oxidation and tyrosine nitration of small and intermediate conductance Ca~(2+)-activated potassium channels, resulting in impaired endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation of resistance arterioles.