To the Editor: The Luschka ducts (LDs) are well-known structures that were described in the 19th century, around the start of the microscope era. However, the recent review of Schnelldorfer et al1 suggests that information on the histo-logic descriptions are limited. In addition, the differential diagnosis with adenocarcinoma remains challenging as recently reported.2 Moreover, the im-munohistochemical profile of LDs has not been reported to our knowledge. We recently observed such lesions in a gallbladder with lithiasic cholecystitis (2 cm calculus). The LD complexes (over 20 complexes, over a 2 cm length; gallbladder length, 9 cm) were situated as a rim in subserosal location, close to the point of adherence of the gallbladder to the liver (Fig. 1). The largest of the LD complexes measured 3.5mm. Myofibro-blasts (smooth muscle actin positive and desmin negative) were more abundant in this subserosal zone, with both concentric and rim-like disposition. The serosa was atrophic. The LDs were either made up of a central duct surrounded by smaller ductules or only of equally sized small ducts. Their form varied from round to collapsed with some angular lumens. The central duct was cystic (3 mm) in only one of these complexes. The epithelial layer was composed of cuboidal cells with regular nuclei.
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