A monoclonal gammopathy in search of clinical significance: 57 years later.

摘要

The articles by Landgren et al and Weiss et al published in a recent issue of Blood provided incontrovertible evidence that all multiple myelomas are preceded by monoclonal gammopathy of undetermined significance (MGUS).1'2 While this association is expected, the findings are important and further strengthen the biologic significance of MGUS. What remains unclear and perhaps the most important question at the moment is the clinical significance of MGUS when there is yet no treatment that can prevent its progression to myeloma. Several clinical questions urgently beg answers.