Platelet integrin signaling: wherefore art thou?

摘要

Rapid-spiking, short-lived, calcium signals using intracellular calcium stores ai generated by alpha 2 beta 1 signaling in a glycoproteii (GP)VI-independent fashion. GPVI is responsible for sustained calcium mobilization dependent on extracellular calcium influx bui requires the presence of alpha 2 beta1 signaling. These findings add complexity to our understanding of how alpha 2 beta 1 and GPVI interact in response to collagen and provide additional evidence that platelet activation and platelet adhesion are not distinct and independent events.