SUSTAINABLE CATALYST FOR FRIEDEL-CRAFTS ACYLATION

摘要

The scope and application of Friedel-Crafts acylation reactions in organic synthesis as well as in industrial processes have advanced extensively. Recent works on the advances in Friedel-Crafts acylations with special importance to organic synthesis covering the developments of methodologies with green and sustainable catalysts are remarkable. Friedel-Crafts acylation is one of the most fundamental unit processes to provide C-C bond and also to incorporate carbonyl functionality into wide varieties of substrates, e.g., aromatics, heterocycles, organo-metallics, etc. But in the era of sustainable environment, the conventional processes were less acceptable in terms of atom economy, overcon-sumption of toxic catalyst [e.g., AlCl_3], etc. Thus, chemists are trying for greener catalytic routes that will be more eco-friendly in nature. In this paper, we have reviewed the use of eco-friendly materials as sustainable catalysts for acylation of aromatics, heterocycles, and ferrocenes. This also includes our own work experiences of using sustainable catalyst metal oxide [e.g., ZnO] with different acid chlorides as acylating agents for aromatics and ferrocenes.