The association of serum uric acid level with coronary collateral circulation should be interpreted together with renal function and cardiovascular medications in stable coronary artery disease

摘要

We read with interest the study by Uysal et al evaluating the association between serum uric acid (SUA) level and coronary collateral circulation (CCC) in patients with stable coronary artery disease (CAD).Several studies reported a relationship between SUA and CCC in acute coronary syndrome but none had previously addressed stable CAD. As a simple, widely available noninva-sive marker, SUA is a useful indicator of inflammation and oxidative stress that have been studied in several cardiovascular diseases. So, for the first time, Uysal et al1 demonstrated a relationship between SUA level and CCC in stable CAD. However, the study has limitations.First, the study lacks data regarding some of the components of metabolic syndrome like dyslipidemia and waist circumference which correlate with SUA levels. Second, the study has no data regarding cardiovascular medications. Among these drugs, the beneficial effects of statins are not only due to the improvement in plasma lipid levels but also due to the action on the vasculature including the improvement in endothelial function, anti-inflammatory, and antithrombotic actions.