Serum gamma-glutamyltransferase (GGT) activity is a marker of oxidative stress and activity is associated with cardiovascular disease. Carotid intima-media thickness (IMT) is a noninvasive predictor of atherosclerosis. We investigated the association between serum GGT activity and carotid IMT. Fifty-five persons who had normal liver function tests were consecutively enrolled. Carotid IMT was evaluated in the right and left common carotid arteries. The averaged values of carotid IMT and serum GGT activity were compared. Serum GGT activity correlated with carotid IMT (r = .396, P = .003). Serum GGT activities were increased in patients with carotid intimal hyperplasia compared with those without intimal hyperplasia (20.3 +/- 11.2 vs 34.3 +/- 16.1 U/L; P = .001). Serum GGT activity is associated with carotid IMT. This finding supports the concept that elevated serum GGT activity is a marker of atherosclerosis.
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机译：血清γ-谷氨酰转移酶（GGT）活性是氧化应激的标志物，其活性与心血管疾病有关。颈动脉内膜中层厚度（IMT）是动脉粥样硬化的非侵入性预测因子。我们调查了血清GGT活性和颈动脉IMT之间的关联。连续入选了肝功能检查正常的55人。在左右颈总动脉中评估颈动脉IMT。比较了颈动脉IMT和血清GGT活性的平均值。血清GGT活性与颈动脉IMT相关（r = .396，P = .003）。与没有内膜增生的患者相比，患有颈动脉内膜增生的患者的血清GGT活性增加（20.3 +/- 11.2 vs 34.3 +/- 16.1 U / L; P = .001）。血清GGT活性与颈动脉IMT有关。这一发现支持了血清GGT活性升高是动脉粥样硬化的标志的概念。
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