Epigenetic scores for the circulating proteome replicate protein-disease predictions as tools for biomarker discovery (Updated April 28, 2021)

摘要

2021 MAY 07 (NewsRx) - By a News Reporter-Staff News Editor at Disease Prevention Daily - According to news reporting based on a preprint abstract, our journalists obtained the following quote sourced from biorxiv.org: "Polygenic scores capture the genetic predisposition to complex disease and are powerful tools for risk stratification. "However, such diseases are also largely influenced by environmental insults and lifestyle factors, which are thought to be captured by epigenetic modifications. DNA methylation encodes information on the epigenetic landscape of an individual, regulates gene transcription, and can be reflected in the variability of the proteome. Protein biomarkers that predict or correlate with disease onset have been identified across many age-related morbidities; however, the extent of epigenetic influence in these pathways is often unclear. Here, we report a comprehensive epigenome-wide study of the circulating proteome.