首页> 外文期刊>Antiviral therapy >Upregulation of NKG2C+ natural killer cells, TLR-2 expression on monocytes and downregulation of regulatory T-cells influence PEG-IFN treatment efficacy in entecavir-suppressed patients with CHB.
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Upregulation of NKG2C+ natural killer cells, TLR-2 expression on monocytes and downregulation of regulatory T-cells influence PEG-IFN treatment efficacy in entecavir-suppressed patients with CHB.

机译:NKG2C +自然杀伤细胞的上调,单核细胞上TLR-2的表达以及调节性T细胞的下调会影响恩替卡韦抑制的CHB患者的PEG-IFN治疗功效。

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摘要

Successful response to PEG-IFN-α correlates with an early significant restoration of impaired immune responses. Although antiviral treatment response can be achieved by both IFN and ETV, the underlying immunological features vary which may explain the generally observed difference in off-treatment durability of response between the two treatments, as well as effects on HBsAg.
机译:对PEG-IFN-α的成功应答与受损免疫应答的早期显着恢复有关。尽管IFN和ETV均可实现抗病毒治疗反应,但潜在的免疫学特征有所不同,这可能解释了两种治疗之间通常观察到的治疗后反应持久性差异以及对HBsAg的影响。

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