Donor dendritic cells dance the do-si-do in allogeneic transplantation

摘要

The current paradigm for understanding engraftment in allogeneic hematopoietic progenitor cell transplantation is that donor T cells facilitate engraftment by donor stem cells, host dendritic cells (DCs) activate donor T cells and induce graft versus host disease (GVHD), and host T cells mediate graft rejection. The role for donor DCs has been neglected due, in part, to their scarcity in bone marrow grafts, assumptions of limited survival in allogeneic recipients after transplantation, and the overwhelming larger numbers of host DCs that are capable of directly presenting alloantigen to donor T cells. A novel finding in the report by Taylor et al relates to a role for donor DCs in modulating engraftment