Repertoire isn't everything for GVHD.

摘要

The transplant field continues to search for strategies to prevent GVHD after alloge-neic HCT while maintaining the beneficial affects of donor T cells including engraftment,antitumor responses, and immune reconstitu-tion. A number of groups have demonstrated that CD4 and CD8 T_EM cells differ from other subsets because unlike T_N or T_cm cells, the former fail to induce significant GVHD in several experimental model systems. Despite such observations, evidence continues to accumulate that T_Em cells provide antitumor reactivity, the raison d'etre of most allogeneic HCTs. Thus, understanding why T_em cells behave differently from other subsets could lead to promoting the use of multiple T-cell populations to minimize complications and maximize the benefits of allogeneic HCT.