GATA-3 locks the door to the B-cell option.

摘要

T cells and B cells share many L developmental requirements, starting with the parallel checkpoints in both pathways that are dependent on the activation of Ragl-Rag2 DNA recombinase and Rag-mediated immune receptor gene rearrangements. A close developmental relationship has seemed self-evident: the first partially restricted hematopoietic progenitor cell type to be defined prospectively was the common lymphoid precursor, a stem cell descendant that retains both T- and B-lineage potential while other potentials are reduced or eliminated.