Use of PLS3, Twist, CD158k/KIR3DL2, and NKp46 gene expression combination for reliable S??zary syndrome diagnosis

摘要

Several publications, including ours, reported that T-plastin (PLS3) is specifically expressed in patients with Sezary syndrome (SS), the erythrodermic and leukemic form of cutaneous T-cell lymphoma (CTCL). Besides PLS3, several other molecular SS-restricted markers, including the transcription factor Twist, have been identified by gene expression analysis on whole peripheral blood mononuclear cells. We also previously reported SS malignant cells characterization by their membrane expression of CD158k/ KIR3DL2 and CD335/NKp46. Here we investigated whether PLS3, Twist, KIR3DL2, and NKp46 gene expression profiling by quantitative PCR (qRT-PCR) can be used for an efficient molecular SS diagnosis.