MiR-142 keeps CD4+ DCs in balance

摘要

Dendritic cells (DCs) are a rare type of white blood cell that play a critical role in bridging the innate and adaptive immune system. They are essential for presentation of both endogenous (self-) antigens and foreign (pathogen-derived) antigens and as such constitute a frontline defense against microorganisms. To effectively provide immune protection, different DC subsets have evolved.The genetic program that coordinates the development of these subsets is controlled largely by cytokines and transcription factors.2 Interferon regulatory factors (Irf), namely Irf4 and Irf8, are essential for the development of CD4+ and CD8+ DC lineages, respectively, in mice, and PU. 1 is a pioneering transcription factor for myeloid cell development (see figure).