Synthesis and anti-HIV activity of some novel arylphosphate and H-phosphonate derivatives of 3'-azido-2',3'-dideoxythymidine and 2',3'-didehydro-2',3'-dideoxythymidine.

Cardona VM; Ayi AI; Aubertin AM; Guedj R

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Synthesis and anti-HIV activity of some novel arylphosphate and H-phosphonate derivatives of 3'-azido-2',3'-dideoxythymidine and 2',3'-didehydro-2',3'-dideoxythymidine.

机译：3'-叠氮基-2'，3'-二脱氧胸苷和2'，3'-二氢-2'，3'-二脱氧胸苷的一些新型芳基磷酸酯和H-膦酸酯衍生物的合成及其抗HIV活性。

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摘要

Phosphate and H-phosphonate derivatives of anti-HIV nucleoside analogues (AZT and d4T) were prepared as potential prodrugs of the bio-active free nucleotide and they were evaluated for their inhibitory effects on the replication of HIV-1 in several cell culture systems. One compound exhibited an important anti-HIV-1 activity and proved to be significantly more efficient than the parent nucleoside.

机译：制备抗HIV核苷类似物（AZT和d4T）的磷酸酯和H膦酸酯衍生物作为生物活性游离核苷酸的潜在前药，并评估它们在几种细胞培养系统中对HIV-1复制的抑制作用。一种化合物表现出重要的抗HIV-1活性，并且被证明比母体核苷有效得多。

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《Antiviral Research》 |1999年第3期|共8页
作者
Cardona VM; Ayi AI; Aubertin AM; Guedj R;
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正文语种 eng
中图分类药学;
关键词
Anti-HIV Agents; HIV-1; Reverse Transcriptase Inhibitors; Stavudine; Zidovudine; 抗HIV药; HIV-1; 逆转录酶抑制剂; 司他夫定; 齐多夫定;

机译：Anti-HIV Agents;HIV-1;Reverse Transcriptase Inhibitors;Stavudine;Zidovudine;抗HIV药;HIV-1;逆转录酶抑制剂;司他夫定;齐多夫定;

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1. Synthesis and anti-HIV activity of some novel arylphosphate and H-phosphonate derivatives of 3'-azido-2',3'-dideoxythymidine and 2',3'-didehydro-2',3'-dideoxythymidine. [J] . Cardona VM, Ayi AI, Aubertin AM, Antiviral Research . 1999,第3期

机译：3'-叠氮基-2'，3'-二脱氧胸苷和2'，3'-二氢-2'，3'-二脱氧胸苷的一些新型芳基磷酸酯和H-膦酸酯衍生物的合成及其抗HIV活性。
2. Synthesis and anti-HIV activities of phosphate triester derivatives of 3'-fluoro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine [J] . Hitesh K. Agarwal, Gustavo F. Doncel, Keykavous Parang Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2008,第33期

机译：3'-氟-2'，3'-二脱氧胸苷和3'-叠氮基-2'，3'-二脱氧胸苷的磷酸三酯衍生物的合成及抗HIV活性
3. Synthesis and biological evaluation of fatty acyl ester derivatives of 2',3'-didehydro-2',3'-dideoxythymidine. [J] . Agarwal HK, Loethan K, Mandal D, Bioorganic and Medicinal Chemistry Letters . 2011,第7期

机译：2′，3′-二脱氢-2′，3′-二脱氧胸苷的脂肪酰基酯衍生物的合成和生物学评价。
4. Synthesis and Anti-HIV Integrase Inhibitory Activity of β-Diketo Derivatives of Mono-Substituted Calix arene [C] . Zaigang Luo, Xuemei Xu, Mingyang Zhang, International Conference on Chemical, Material and Metallurgical Engineering . 2013

机译：单替代胶芳烃β-Diketo衍生物的合成与抗HIV整合酶抑制活性
5. Synthesis of potential anti-HIV agents and prodrugs: Part I synthesis of L-3'-hydroxymethylnucleosides. Part II synthesis and pharmacokinetics of 3'-azido-2',3'-dideoxyuridine (AZDU) as prodrugs . [D] . Cooperwood, John Steven. 1999

机译：潜在的抗HIV药物和前药的合成：第I部分L-3'-羟甲基核苷的合成。第二部分3'-叠氮基2'，3'-二脱氧尿苷（AZDU）作为前药的合成和药代动力学。
6. d- and l-2′3′-Didehydro-2′3′-Dideoxy-3′-Fluoro-Carbocyclic Nucleosides: Synthesis Anti-HIV Activity and Mechanism of Resistance [O] . Jianing Wang, Yunho Jin, Kimberly L. Rapp, -1

机译：d-和l-23-Didehydro-23-Dideoxy-3-氟-碳环核苷：合成抗HIV活性和耐药机制
7. 2′,3′-Didehydro-2′,3′-dideoxythymidine (D4T), an anti-HIV Agent [O] . M. J. M. Hitchcock 1991

机译：2'，3'- didehydro-2'，3'-二脱氧胸苷（D4t），抗HIV剂

Synthesis and anti-HIV activity of some novel arylphosphate and H-phosphonate derivatives of 3'-azido-2',3'-dideoxythymidine and 2',3'-didehydro-2',3'-dideoxythymidine.

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