Effect of recombinant human interferon alpha B/D (rHu-IFN-alpha B/D) in combination with acyclovir in experimental HSV-1 encephalitis.

Wintergerst U; Gangemi JD; Whitley RJ; Chatterjee S; Kern ER

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Effect of recombinant human interferon alpha B/D (rHu-IFN-alpha B/D) in combination with acyclovir in experimental HSV-1 encephalitis.

机译：重组人干扰素αB / D（rHu-IFN-αB / D）联合无环鸟苷在实验性HSV-1脑炎中的作用。

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The efficacy of recombinant human interferon alpha B/D in experimental HSV-1 encephalitis was investigated in the murine system. Recombinant Hu-IFN-alpha B/D significantly reduced the mortality in a mouse encephalitis model (about 30%, P = 0.021), whereas natural mouse interferon was inactive. Combination of acyclovir with Hu-IFN-alpha B/D had an additive effect.

机译：在鼠类系统中研究了重组人干扰素αB / D在实验性HSV-1脑炎中的功效。重组的Hu-IFN-αB / D可以显着降低小鼠脑炎模型的死亡率（约30％，P = 0.021），而天然小鼠干扰素则没有活性。阿昔洛韦与Hu-IFN-αB / D的组合具有加和作用。

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《Antiviral Research》 |1999年第1期|共4页
作者
Wintergerst U; Gangemi JD; Whitley RJ; Chatterjee S; Kern ER;
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正文语种 eng
中图分类药学;
关键词
Acyclovir; Antiviral Agents; Encephalitis; Herpes Simplex drug therapy; Herpesvirus 1; Human; 阿昔洛韦; 抗病毒药; 疱疹病毒1型; 人;

机译：Acyclovir;Antiviral Agents;Encephalitis;Herpes Simplex drug therapy;Herpesvirus 1;Human;阿昔洛韦;抗病毒药;疱疹病毒1型;人;
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1. Effect of recombinant human interferon alpha B/D (rHu-IFN-alpha B/D) in combination with acyclovir in experimental HSV-1 encephalitis. [J] . Wintergerst U, Gangemi JD, Whitley RJ, Antiviral Research . 1999,第1期

机译：重组人干扰素αB / D（rHu-IFN-αB / D）联合无环鸟苷在实验性HSV-1脑炎中的作用。
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6. Synergistic activity of combinations of recombinant human alpha interferon and acyclovir administered concomitantly and in sequence against a lethal herpes simplex virus type 1 infection in mice. [O] . E V Connell, R L Cerruti, P W Trown 1985

机译：重组人α干扰素和阿昔洛韦的组合同时并按顺序给药对小鼠的致命1型单纯疱疹病毒感染具有协同作用。
7. Synergistic activity of combinations of recombinant human alpha interferon and acyclovir, administered concomitantly and in sequence, against a lethal herpes simplex virus type 1 infection in mice. [O] . Connell, E V, Cerruti, R L, Trown, P W 1985

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8. Novel Plant-Derived Recombinant Human Interferons with Broad Spectrum Antiviral Activity. [R] . Koehler, J. W., Dupuy, L. C., Garrison, A. R., 2011

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Effect of recombinant human interferon alpha B/D (rHu-IFN-alpha B/D) in combination with acyclovir in experimental HSV-1 encephalitis.

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