THE GATEWAY TO DIFFICULT SEPARATIONS, SELECTIVITY OR EFFICIENCY?

摘要

Separations scientists are facing an increasing number of HPLC Columns that are offering either orthogonal selectivity or extremely high plate numbers (efficiency) compared to those available say, 5 years ago. When faced with new separations that need to be performed, and in many cases these are getting more complex, which route do they opt to pursue at the method development stage?