Collaboration to Characterise Highly Unstable Polymorph of Pharmaceutical Compound

摘要

Chemlmage is pleased to announce publication of the results of a collaborative study with the FDA to characterise the thermodynamics of a highly unstable polymorph of acetaminophen. The Journal of Pharmaceutical and Biomedical Analysis, a peer-reviewed journal, published Raman detected differential scanning calorimetry of polymorphic transformations in acetaminophen. This publication outlines the application of a method for polymorph characterisation, which combines differential scanning calorimetry (DSC) and Raman microscopy. Interest in the polymorphic forms of acetaminophen comes as a result of the poor compression properties of the form used commercially in common pain relievers. An understanding of thermally driven polymorphic transformations is essential to the development and, ultimately, the use of another form that has improved compression properties with the same pharmacological effects.