Cadmium chronic administration to lactating ewes:Reproductive performance,cadmium tissue accumulation and placental transfer

摘要

20 lactating ewes were allotted to two groups:10 subjects received orally 100 mg/day of CdCl_2 for 108 consecutive days,and the remaining 10 acted as control.Reproductive performance in ewes and cadmium tissue accumulation,both in ewes and their lambs,were investigated.The results showed that in ewes:1) the regular cadmium intestinal intake negatively influences all reproductive parameters; 2) cadmium is particularly accumulated in kidney and liver,but also in mammary gland,although at a distinctly lower level; 3)chronic administration does not increase cadmium placental transfer in lactating pregnant subjects.