Targeting TGF beta Signalling in Cancer: Toward Context-Specific Strategies

摘要

The transforming growth factor beta (TGF beta) signalling pathway regulates a range of important cellular processes in a context-dependent manner. Recent discoveries have provided important insights into the regulation of the TGF beta pathway and its change from an antitumorigenic to a protumorigenic pathway. These findings may have important implications for cancer stem cell (CSC) functions and therapeutic strategies.