Nanoparticles and membrane anisotropy.

摘要

In our work using Aconitum napellus, we predicted that after repeated dilution the aggregates of drug molecules reduce in size and approach the range of nanodimensions.' We showed for the first time the effect of this size reduction due to dilution on membrane anisotropy. At high dilutions, when the size of the drug cluster is in the nanorange, membrane anisotropy increases with increasing dilution, indicating that more drag molecules have entered in the membrane moiety.