Perineurioma versus fibroblastic polyp of the colon.

摘要

Recently, Hornick et al described 8 cases of mucosal perineurioma of the colon, with typical immunoreactivity for EMA and claudin-1. The authors mention that morphologic features of these mucosal cases are similar to those of so-called fibroblastic polyp (FP) that was described also quite recently. Comparing the described features of mucosal perineurioma with features of FP, we also believe that a question arises whether mucosal perineurioma and FB do not represent the same lesion. For this reason, we decided to search for perineurial cell features in our series of 5 cases classified as FP, of which 4 were published previously.We performed immuno-stains for new perineurial markers claudin-1 (polyclonal, 1:50, MW, Zymed) and glut-1 (polyclonal, 1:200, Dako).In addition, the im-munostain for EMA that gave previously negative results was repeated with use of higher primary antibody concentration (1:200 instead of 1:1000; clone E29, Dako). In 1 case, we have searched for ultrastructural features of perineurioma, examining tissue from paraffin block.