Extracavitary KSHV-positive solid lymphoma: A large B-cell lymphoma within the spectrum of primary effusion lymphoma

摘要

We read with great interest the article by Pan et al,1 which appeared in the issue of August 2012 of the The American Journal of Surgical Pathology. The authors investigated the clin-icopathologic features of 9 cases of Kaposi sarcoma-associated herpesvirus (KSHV)-associated large B-cell lym-phomas without lymphomatous effusions in any body cavities. These lymphomas were originally termed "extracavitary KSHV-positive solid lymphoma." Pan et aP also reviewed additional 43 cases of extracavitary KSHV-positive solid lymphomas and compared them with 84 cases of classic primary effusion rymphoma (PEL)4 from the literature. The authors found different clinical presentations and some variations in immunophenotype between extracavitary KSHV-positive solid lymphomas and classic PEL and concluded that it is still uncertain whether it is justifiable to separate them as 2 distinct entities.1 Nevertheless, they recommended the diagnostic term "KSHV-associated large B-cell lym-phoma (KSHV-LBL)" to replace many different names previously used.