Synthesis of Multisubstituted Pyridin-2(3H)-ones via Nickel-Catalyzed Intermolecular Condensation of β-Ketobutylanilides

摘要

A nickel-catalyzed intermolecular condensation of b-ketobutylanilides to synthesize multi-substituted pyri-din-2(3H)-ones was described. To the best of our knowledge, there is no report on the synthesis of these compounds. All the tested substrates with various functional groups irrespective of their nature, whether electron-donating or –withdrawing, and the location of the substituents on the aromatic rings, were all tolerated under the standard conditions and smoothly transformed into the desired products with 71%-86% yields. This strategy provides an efficient approach to valuable pyridin-2(3H)-ones via a sequential dehydration processes which may find applications in natural products and medicinal chemistry.