Evaluation of the causal effects between subjective wellbeing and cardiometabolic health

摘要

Study question Does subjective wellbeing (that is, subjective happiness and life satisfaction) have a causal association with cardiometabolic health? Methods Two sample, bidirectional mendelian randomisation was used to test causal pathways between subjective wellbeing and 11 measures of cardiometabolic health (coronary artery disease; myocardial infarction; total, high density lipoprotein, and low density lipoprotein cholesterol; diastolic and systolic blood pressure; body fat; waist to hip ratio; waist circumference; and body mass index). Summary data from previous genome-wide association studies were used (number of participants ranging from 83198 to 339 224), and a follow-up analysis included 337112 individuals from the UK Biobank (54% female (n=181363), mean age 56.87 years (SD 8.00) at recruitment).