New 1,1'-Ferrocene Bis(sulfonyl) Reagents

摘要

Several new 1,1'-bis(sulfonyl)ferrocenes designed for the syn- thesis of sulfonamide linked biological conjugates have been prepared. 1,1'-Bis(sulfonylbromide)ferrocene can be produced from the corresponding sulfonylchloride via a bis(sulfonylhy- drazide) intermediate. Bis(sulfonyl-N-hydroxybenzotriazole)fer- rocene can also be synthesized from the sulfonyl chloride, and reaction of glycine methyl ester with the sulfonyl chloride affords a [3]ferrocenophane complex. All new compounds have been structurally characterized by X-ray crystallography