DNA-Decorated Luminescent Vesicles as Drug Carriers

摘要

DNA based spherical nanostructures is one of the promising nanocarriers for drug delivery applications because of their ex- cellent biocompatibility and unique structural features of DNA. Herein, we report the amphiphilicity driven self-assembly of DNA-phenyleneethynylene based amphiphile into luminescent vesicles and their cellular uptake toward HeLa cell. Spectro- scopic and microscopic analyses reveal the self-assembly of this class of amphiphiles into vesicular nanostructures with corona made of DNA and a functional hydrophobic membrane. Vesi- cles exhibit promising cell permeability.