Palladium–catalyzed Mizoroki–Heck Reaction Using Imidazo[1,5-a]pyridines

摘要

We designed a new class of N-type ligands bearing an imidazo [1,5-a]pyridine moiety and synthesized seven imidazo[1,5-a]pyr- idine derivatives. The palladium-catalyzed Mizoroki–Heck re- action of aryl bromides and chlorides with alkenes using our imidazo[1,5-a]pyridine-PdCl_2 system afforded the desired prod- ucts in good-to-high yields with the low palladium loadings and short reaction times.