The Ritter Reaction of 2-Oxoaldehydes at Room Temperature: Divergent Behaviour towards Acid Strength.

摘要

An efficient, novel, atom economical and selective amidation method for the generation of mono and di-Ritter products using 2-oxoaldehydes under acidic environment at room temperature was successfully developed. The di-Ritter products obtained are accessed in good yields when stirred in the presence of 20 mol % H2SO4, and the mono products were selectively obtained in moderate yields with CuOTf as catalyst. However, the yields of the latter were optimized by the addition of SeO2.