Synthetic Studies toward the Revised Aglycone of Mandelalide A

摘要

Synthesis of a silyl derivative of revised aglycone of marine anticancer macrolide Mandelalide A is described. The synthetic highlights include acid catalyzed epoxide opening, Chelationcontrolled Grignard reaction, Still-Gennari olefination, Pd-catalyzed intramolecular alkoxycarbonylation, Kocien’ski-Julia olefination and Shiina macrolactonization as keysteps.