Hydroxyurea makes inflammation 'just right'?

摘要

Why was this study conducted in an animal model? Why use mouse models to examine major clinical issues of pneumococcal infection and hydroxyurea in sickle cell disease (SCD), well-traveled roads of investigation with abundant clinical data? In this issue of Blood, Lebensburger and colleagues make elegant use of genetically modified mice to investigate mechanisms of SCD pathophysiology and mechanisms of therapy. New hypotheses generated with the animal data were then tested with analysis of clinical samples, providing a fine example of the utility of animal models and translational research.