A-One Pot Four Component and Microwave-Assisted Synthesis of Pyrrolo [1, 10]phenanthrolines

摘要

Microwave-assisted synthesis of pyrrolo[1, 10]-phenanthrolines in a one pot four component approach afforded a wide range of products within 3 minutes. All the compounds were screened for their biological activities such as anti-microbial and anti-cancer activities. Compounds 5b, 5 c, 5 i, 5m and 5n have shown more potent activity when compared to standard doxorubicin against AGS cancer cell line and compounds 5d and 5l show more potent microbial activity against MRSA, B. Subtilis and C. Albicans when compared to standard Erythromycin, Oxacillin and Ketoconazole