ESP-Promoted Suzuki-Miyaura Cross-Coupling and Peptide Bond Formation Reactions in Water at Room Temperature

摘要

A potential green protocol for C-C and C-N bond formation reactions in aqueous medium promoted by basic waste biomass has been developed. The protocol involves the use of Egg Shell Powder (ESP) in water as a green heterogeneous reaction media which is basic in nature and offers a mild, resourceful and inexpensive alternative to the conventional protocols for palladium catalyzed C-C (Suzuki-Miyaura) and C-N (Peptide coupling) bond formation reactions. The reac- tions proceeded in basic ESP medium in air at short reaction time at room temperature under ‘external base/external promoter/ligand/organic solvent’ free conditions.