A Facile and Efficient Synthesis of Oxindole Scaffolds through Linear Regioselective Reductive Coupling between Vinyl Sulfones and Isatins/Isatinimines

摘要

Zn/CeCl_3.7H_2O mediated facile and an efficient synthesis of oxindoles motifs via linear regioselective reductive coupling between isatin/isatinimine derivatives and vinyl sulfones at room temperature has been described. This synthetic protocol is base free and allow for the synthesis of wide variety of oxindole motifs in moderate to high yields. This is the first example of Mannich-type coupling between isatinimines and vinyl sulfones.