Aleukemic variant of mast cell leukemia

摘要

A 45-year-old woman was admitted with fatigue, icterus, thrombocytopenia (77 X 109/L), normocytic anemia (9.8 g/dL), and a normal white blood cell count (8.5 X 109/L). The peripheral blood smear showed metamyelocytes, myelocytes, monocytes, erythroblasts, and atypical cells with bilobulated nuclei resembling basophil granulocytes (left panel of figure). In the bone marrow there was a nearly complete infiltration with atypical, partly degranulated mast cells expressing surface markers (CD2, CD25, and CD117; right panel of figure).