Aqueous Chloroplatinic Acid: A Green, Chemoselective and Reusable Catalyst for the Deprotection of Acetals, Ketals, Dioxolanes and Oxathiolanes

摘要

Aqueous chloroplatinic acid (H2PtCl6) as an effective catalyst for the deprotection of acetals, ketals, 1,3-dioxolanes and 1,3- oxathiolanes to the corresponding carbonyl compounds in 56- 99% yield has been reported. In addition, the catalyst has highselectivity in cleaving vicinol diol protection, yielding monoprotected diols from di-protected diols as a product. The present deprotection method is novel, chemoselective and offers broad functional group tolerance with short reaction time. Besides, the reaction protocol can be accomplished at ambient temperature and the catalyst is reusable.