Synthesis and DNA-Binding Studies of A New Cyclic Dimeric Symmetrical Pseudo-Turn Mimetic

摘要

A new dimeric cyclic 24 member symmetrical turn analogue was synthesized efficiently by an intramolecular Heck reaction. This facile reaction has produced selectively a single dimeric product having two sets of intramolecular hydrogen bonds (IHB) at the two ends of it. Different experimental studies have unambiguously proved the presence of a pseudo-turn like structure. Furthermore, it was shown that this molecule binds to the minor groove of DNA just like a known minor groove binder, DAPI (4',6-diamidino-2-phenylindole).