Immune thrombocytopenia is an autoimmune bleeding disorder due to enhanced peripheral platelet destruction and reduced bone marrow platelet production. Antibodies and T cells are involved in the pathogenesis of the disease and, like other autoimmune diseases, patients with ITP have a peripheral deficiency of Treg numbers and function that may be responsible for loss of tolerance.2 Li et al now report an additional defect in the peripheral immune regulatory compartment of ITP patients, namely in the Bregs.
展开▼
