A Visible-Light-Mediated Protocol: One-Pot-Three-Component, Sustainable Synthesis of 1,3,4-Thiadiazines

摘要

An expeditious and proficient pH dependent, multicomponent strategy assisted by visible light for the synthesis of highly biologically significant scaffold "1,3,4-thiadiazines" and its derivatives, has been reported here. The hallmark of the present protocol is the utilization of visible light at room temperature to form C- S and C- N bond via generation of some free radical intermediates followed by intramolecular cyclization without employing harsh reaction conditions. It also includes some other attributes like being environmentally benign and cost effective, involving short reaction time and possessing adaptability towards a wide range of substrates with good to excellent yield of product.