ACE Insertion/Deletion Polymorphism and Its Relation-ships to the Components of Metabolic Syndrome in ElderlySlovaks

摘要

The purpose of this study was to assess clustering of Metabolic Syndrome com-ponents in aged Slovaks, and to investigate whether insertion/deletion (I/D) polymorphism ofthe human angiotensin-converting enzyme (ACE) gene is associated with this syndrome.Data were available from 374 Slovak participants (200 females and 174 males) ranging in agebetween 60 and 90 years. ACE I/D polymorphism was determined by PCR amplification ofthe ACE gene sequence. Metabolic Syndrome was diagnosed according to criteria in theNCEP ATP-III. Elderly males and females differ significantly in the prevalence of MetabolicSyndrome (females 45.1 %, males 24.8 %). The males and females including subjects withand without metabolic syndrome, respectively, did not differ significantly in the three geno-type distributions (p = 0.603 and p = 0.247). The allele frequencies (D = 0.5483, I = 0.4517)in the entire sample fell within the Hardy-Weinberg equilibrium. There was no confirmedassociation between ACE genotype and phenotypic variation in the recognized risk compo-nents for Metabolic Syndrome in elderly Slovaks. Among other factors which may induce adifference in Metabolic Syndrome, significant effect was detected for sex, BMI, HDL, TG,glucose and the ApoB/ApoAl ratio.