Condition-Based Selective Synthesis of 3,4,5-Trisubstituted Isoxazoline N-oxides, 4,5-Dihydroisoxazoles and Isoxazoles

摘要

Functionalized isoxazoline /V-oxides, 4,5-dihydroisoxazoles and isoxazoles have attracted considerable attention because of their wide applications. Starting from 1,1-dimethoxy-2-nitro-ethene and aldehydes, a cascade approach to these hetero-cycles was explored to achieve structural diversity controlled by different reaction conditions. Furthermore, this new protocol provided a direct access to 4-substituted-3,5-bis(methoxycar-bonyl)-4,5-dihydroisoxazoles from aromatic aldehydes for the first time.