Fluorine-Containing n-6and Angular and Linear n-6-n’(n,n’ = 5,6,7)Diaza-Heterocyclic Scaffolds Assembled on Benzene Core in Unified Way

摘要

The title compounds,including hybrids(n ≠ n’),were assembled on benzene core in a unified way based on only one starting material C6F5NH2 and a limited number of simple substitution and condensation reactions.The heterocyclic moieties were 1,3-diazoles,1,2,3-triazoles,1,2,5-thia(selena)diazoles,1.4-diazines and 1,5-diazepines,as well as 1,3,2-dioxaboroles.Representatives of all new scaffolds were characterized by XRD.Compounds synthesized are of biomedical interest in the context of apoptotic anticancer activity,and the 1,2,5-thiadiazole/1,3,2-dioxaborole hybrid also in that of neutron or/and proton capture therapy of cancer.New 1,2,5-chalcogenadiazoles are protected forms of otherwise hardly accessible fluorine-containing di-and tetra-amines for further syntheses.