Synthetic Utilization of α,β-Chalcone Dibromide In Heterocyclic Chemistry and Stereoselective Debromination

摘要

This review article epitomize the different synthetic approaches to synthesize α,β-chalcone dibromide and their application in developing chemically and biologically relevant heterocyclic compounds. The transformation of α,β-chalcone dibromide into aziridines, pyrazolines, pyrazoles, isoxazoles, pyridine, pyrimidine, flavanoids, diazepines and other heterocyclic com- pounds has been described briefly in different categories to highlight the importance of these α,β-chalcone dibromide as key intermediate in organic chemistry. Stereoselective debromi- nation of α,β-chalcone dibromides with various metal-contain- ing reducing agents, metal-metal salt system, ionic liquid, solvents and photoredox catalyst to their corresponding chalcones is also described.